Abstract Summary
Objective
This study investigates the potential negative side effects and concernss of consuming ashwagandha (Withania somnifera), a popular adaptogenic herb. The research focuses on its adverse interactions with certain medications, potential side effects for specific populations, and the impact of excessive consumption.
Context
Ashwagandha is widely used in traditional medicine and modern supplements for its purported benefits in reducing stress, improving cognitive function, and boosting immunity. Despite its widespread use, there are certain concerns regarding its safety profile, especially for individuals with specific medical conditions or those on particular medications. Understanding these side effects is important to help users make informed decisions about its consumption.
Methods Used
Approach
The study utilized a combination of clinical data review, case studies, and expert opinions to examine the adverse effects and contraindications of ashwagandha. Researchers analyzed scientific literature, safety reports, and clinical trial findings related to ashwagandha's use, focusing on its interactions with prescription drugs, potential side effects, and populations.
Data Collection
Data were collected from published clinical trials, case reports, and expert reviews on the use of ashwagandha. The study also involved the analysis of consumer reports and surveys concerning adverse effects after ashwagandha supplementation. Researchers examined conditions such as thyroid imbalances, autoimmune disorders, and the impact on pregnant or breastfeeding women.
Researchers' Summary of Findings
Impact on Health
While ashwagandha has many proven health benefits, certain groups of people may experience negative side effects or contraindications. These include the possibility of gastrointestinal issues, sedation, and interactions with medications for thyroid conditions, immune disorders, and sedatives. Overuse or high doses of ashwagandha can also lead to potential hormonal imbalances or exacerbate certain pre-existing conditions.
Health Implications
Some of the most significant health concerns identified were
Thyroid Function: Ashwagandha may increase thyroid hormone levels, which can be problematic for individuals with hyperthyroidism or those on thyroid medication.
Immune System: Ashwagandha’s immune-boosting properties may not be suitable for individuals with autoimmune diseases, as it can stimulate the immune system and worsen conditions such as rheumatoid arthritis, lupus, or multiple sclerosis.
Sedation Effects: Ashwagandha may cause drowsiness or interact with sedatives and anti-anxiety medications, potentially leading to excessive sedation.
Pregnancy and Breastfeeding: Its use during pregnancy is not recommended due to a lack of sufficient safety data. High doses of ashwagandha have also been linked to complications in pregnancy, including the possibility of miscarriage.
Sustainability
Promoting safe consumption and sustainable sourcing of ashwagandha can help minimize potential environmental degradation. Encouraging responsible cultivation practices and informed consumer choices will support long-term ecological health, ensuring that this herb remains a viable resource for generations to come.
DOI
10.1007/s00424-025-00984-2
