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Evaluating the Efficacy of Curcumin and Nano-Curcumin in Chronic Pain Management: A Systematic Review and Meta-Analysis
Abstract Summary Objective: To evaluate the efficacy of curcumin and nano-curcumin in alleviating chronic pain in both clinical and preclinical settings. Context: Chronic pain presents significant treatment challenges. Curcumin, a natural compound in the Curcuma genus, is known for its anti-inflammatory, antioxidant, and neuroprotective properties. Methods Used Approach: A systematic review and meta-analysis were conducted to assess the analgesic effects of curcumin and nano-curcumin. Data Collection: Comprehensive searches were performed across PubMed, SCOPUS, Web of Science Core Collection, Cochrane, and Google Scholar up to April 1, 2023. Studies meeting the inclusion criteria were analyzed using mean difference (MD) or standardized...