Abstract Summary
Objective
To investigate the effects of ashwagandha root extract on serum testosterone and inflammatory markers in healthy adults following resistance training.
Context
Ashwagandha's ability to increase testosterone in men and reduce cortisol is expected to promote muscle development, while its antioxidant and anti-inflammatory properties may support muscle recovery.
Methods Used
Approach
A prospective, randomized, double-blind, placebo-controlled study in 80 healthy male and female adults (18–45 years). Participants received 300 mg ashwagandha root extract or starch placebo twice daily for 8 weeks alongside a resistance training program.
Data Collection
Assessments included serum testosterone (total and free), CD4 cell counts, and inflammatory markers (IL-6, TNF-alpha), measured at baseline and at 8 weeks.
Researchers' Summary of Findings
Free serum testosterone levels increased significantly in males receiving ashwagandha compared to placebo (p < 0.0001). IL-6 and TNF-alpha levels were lower in the ashwagandha group, though not statistically significant. Ashwagandha supplementation combined with resistance training effectively improved free testosterone levels in men.
DOI
10.5281/zenodo.10050712
