Learn — Melatonin for jet lag

Abstract Summary Objective The objective of this research is to identify the single most validated supplement for alleviating jet lag–related sleep disturbances, emphasizing results from placebo‑controlled trials, meta‑analyses, and practical effectiveness in real travel conditions. Context Jet lag arises when rapid travel across multiple time zones desynchronizes the body’s internal circadian clock from the local environmental time cues, such as daylight and meals. This misalignment produces symptoms such as disrupted sleep, daytime fatigue, difficulty concentrating, mood disturbance, and gastrointestinal issues. Travelers, frequent flyers, shift workers, and folks crossing more than two time zones often turn to dietary or botanical supplements...