Learn — Melatonin

Abstract Summary Objective To determine how the timing of melatonin intake affects sleep quality and duration through analysis of clinical trials and meta-analyses. Context  Melatonin is a hormone that regulates the sleep-wake cycle. Endogenous levels rise one to two hours before bedtime, and taking supplements during this window enhances sleep onset and quality. Dosing too early or too late can reduce benefits or disrupt circadian rhythm. Methods Used Approach A literature review of randomized controlled trials, pharmacokinetic studies, and meta-analyses was conducted to assess the effects of melatonin timing and dosage on sleep outcomes. Data Collection Data were sourced from...

Abstract Summary Objective To summarize clinical findings on individuals who should avoid or use caution when taking melatonin, based on physiological, pharmacological, and safety considerations. Context Melatonin is a hormone that regulates the sleep–wake cycle. Although generally safe for short-term use, evidence suggests potential risks for specific groups, including children, pregnant individuals, and those with chronic illnesses or medication sensitivities. Methods Used Approach A focused literature review was conducted using data from PubMed, NIH, Mayo Clinic, and NHS health databases. Emphasis was placed on safety data, pharmacological interactions, and hormonal outcomes. Data Collection Clinical and observational studies were reviewed for...

Abstract Summary Objective To examine the common side effects and safety concerns of melatonin use in adults and children. Context Melatonin is widely available over the counter, often taken without medical advice. Understanding its safety profile is key as use increases across all age groups. Methods Used Approach A review of clinical and pharmacological studies from PubMed, Mayo Clinic, and Sleep Foundation focusing on reported adverse effects and medication interactions. Data Collection Data included symptoms such as headache, nausea, dizziness, and daytime drowsiness, as well as reported medication interactions and hormonal concerns. Researchers’ Summary of Findings Impact on Health Melatonin...

You have melatonin in your hand, the lights are low, and you’re ready to relax. But when exactly is the best time to take it?  If you’re just even an hour off… You could not only potentially ruin your night but also throw yourself into a whirlwind of unrest all month long. Melatonin is not like a sleeping pill that knocks you out. It is a hormone—one that your body produces in response to darkness.  And taking it right is working with your body’s rhythm, not against it. So let’s unpack when, why, and how to use melatonin right. The...