Learn — Melatonin Dosage

Abstract Summary Objective The objective of this research is to identify the single most validated supplement for alleviating jet lag–related sleep disturbances, emphasizing results from placebo‑controlled trials, meta‑analyses, and practical effectiveness in real travel conditions. Context Jet lag arises when rapid travel across multiple time zones desynchronizes the body’s internal circadian clock from the local environmental time cues, such as daylight and meals. This misalignment produces symptoms such as disrupted sleep, daytime fatigue, difficulty concentrating, mood disturbance, and gastrointestinal issues. Travelers, frequent flyers, shift workers, and folks crossing more than two time zones often turn to dietary or botanical supplements...

Abstract Summary Objective The objective of this research is to determine the most effective and safest dosage of melatonin for improving sleep outcomes, with a focus on sleep latency, duration, and quality in both general and clinical populations. Context Melatonin, a hormone secreted by the pineal gland, regulates circadian rhythms and sleep-wake cycles. It is widely used as a supplement for conditions like insomnia, jet lag, and circadian rhythm disorders. While it is available over-the-counter, dosage recommendations vary widely. Clinical data suggests that lower doses may mimic physiological levels more effectively, while higher doses can cause side effects or lose...