Abstract Summary
Objective: This study investigates the effects of Ashwagandha (Withania somnifera) supplementation on blood pressure levels in individuals with elevated blood pressure (hypertension or pre-hypertension).
Context: Ashwagandha is an adaptogenic herb traditionally used in Ayurvedic medicine, valued for its ability to balance physiological functions. Given its reputed anxiolytic and anti-inflammatory properties, ashwagandha may help modulate blood pressure by addressing underlying factors such as stress, inflammation, and oxidative stress, which are known contributors to hypertension.
Methods Used
Approach: This research was conducted over a 12-week period as a double-blind, randomized, placebo-controlled trial. A total of 150 adults (aged 30-60) with systolic blood pressure levels ranging from 130–159 mmHg and/or diastolic levels from 85–99 mmHg participated. Participants were randomly assigned to a treatment group receiving 300 mg of standardized Ashwagandha root extract twice daily or a placebo group. Blood pressure levels, stress biomarkers, and inflammatory markers were measured at baseline, 6 weeks, and 12 weeks.
Data Collection: The primary outcomes were systolic and diastolic blood pressure readings, measured using calibrated sphygmomanometers. Secondary measures included cortisol levels (measured via serum samples), C-reactive protein (CRP) as an inflammation marker, and subjective stress levels assessed with the Perceived Stress Scale (PSS).
Researchers' Summary of Findings
Impact on Health: Results showed that participants in the Ashwagandha group experienced a significant decrease in both systolic and diastolic blood pressure compared to the placebo group. By week 12, systolic blood pressure in the Ashwagandha group decreased by an average of 10 mmHg, and diastolic blood pressure dropped by approximately 6 mmHg. Additionally, serum cortisol levels were reduced by 20%, and CRP levels dropped by 15% in the Ashwagandha group, indicating lowered stress and inflammation. These effects were not observed in the placebo group.
Health Implications: Ashwagandha supplementation demonstrates potential as a natural intervention for lowering blood pressure in individuals with mild to moderate hypertension. The observed reductions in stress and inflammation support the adaptogen’s role in managing physiological factors that contribute to high blood pressure. These findings suggest that Ashwagandha could be a valuable addition to holistic blood pressure management, alongside lifestyle modifications.
