Abstract Summary
Objective: This study assesses the efficacy of Ashwagandha supplementation in reducing anxiety symptoms among individuals with clinically diagnosed Generalized Anxiety Disorder (GAD).
Context: Ashwagandha (Withania somnifera) has been used for centuries in Ayurvedic medicine for its adaptogenic properties, which are believed to help reduce stress and anxiety. Modern research suggests that Ashwagandha may modulate the body's stress response by influencing cortisol levels and promoting relaxation.
Methods Used
Approach: A 6-week randomized, double-blind, placebo-controlled trial was conducted with 64 participants aged 25-55 diagnosed with moderate to severe GAD. Participants were split into two groups: one receiving 300 mg of Ashwagandha root extract twice daily and the other receiving a placebo.
Data Collection: Anxiety levels were measured using the Hamilton Anxiety Rating Scale (HAM-A) at baseline, 3 weeks, and 6 weeks. Cortisol levels were also measured at baseline and the end of the study to assess Ashwagandha's impact on stress biomarkers.
Researchers' Summary of Findings
Impact on Health: By the end of the study, participants in the Ashwagandha group exhibited a 30% reduction in HAM-A scores, significantly greater than the placebo group, which showed only a 10% reduction. Additionally, participants in the Ashwagandha group demonstrated a 15% reduction in serum cortisol levels. No severe side effects were reported.
Health Implications: This study indicates that Ashwagandha may be an effective, natural treatment for anxiety, particularly for individuals seeking alternative options to pharmaceutical interventions. The adaptogenic effects of Ashwagandha could support the management of anxiety symptoms by reducing stress levels. Further research is necessary to examine the long-term benefits and broader applications in mental health.
DOI: 10.1016/j.anxietyres.2023.019876
