Abstract Summary
Objective
This research aims to evaluate the therapeutic potential of turkey tail mushrooms (Trametes versicolor) in enhancing immune function and supporting adjunctive cancer therapies. The focus is on understanding the bioactive compounds responsible for these effects and assessing their implications for clinical use.
Context
Turkey tail mushrooms have been utilized in traditional medicine, particularly in Asia, for their health-promoting properties. Modern research has identified key polysaccharopeptides, such as PSK (polysaccharide-K) and PSP (polysaccharide-peptide), which are believed to modulate immune responses. These compounds have been studied for their potential to support immune function and as complementary agents in cancer treatment protocols.
Methods Used
Approach
A comprehensive literature review was conducted, sourcing peer-reviewed articles from databases like PubMed and Google Scholar. The review focused on studies examining the biochemical properties of turkey tail mushrooms, their effects on immune modulation, and their role in cancer therapy.
Data Collection
The data set includes clinical trials, in vitro and in vivo studies, and meta-analyses that explore the efficacy of turkey tail mushroom extracts, particularly PSK and PSP, in modulating immune responses and supporting cancer treatments. Notably, studies have investigated their use in breast, gastric, and colorectal cancers.
Researchers’ Summary of Findings
Health Implications
Turkey tail mushrooms contain bioactive compounds that may enhance immune function by stimulating cytokine production and increasing the activity of natural killer cells. Clinical studies suggest that these effects can improve the efficacy of conventional cancer treatments and support recovery post-therapy.
Additionally, turkey tail mushrooms have been associated with gut health benefits, acting as prebiotics to promote beneficial gut bacteria, which in turn supports overall immune health.
Sustainability
Turkey tail mushrooms are saprophytic fungi that decompose dead wood, playing a vital role in forest ecosystems. They can be sustainably cultivated on agricultural waste products, such as sawdust and straw, reducing the need for wild harvesting and minimizing environmental impact.
DOI
10.1186/s12906-019-2681-7
