Abstract Summary
Objective: This study examines the effects of Ashwagandha (Withania somnifera) supplementation on blood pressure levels in individuals with mild to moderate hypertension. The aim is to evaluate whether Ashwagandha, known for its adaptogenic properties, can significantly reduce systolic and diastolic blood pressure.
Context: Ashwagandha has been traditionally used in Ayurvedic medicine for its potential to regulate stress responses and promote overall health. Recent studies suggest it may have cardiovascular benefits, including its potential to lower blood pressure due to its stress-reducing and anti-inflammatory properties. This research focuses on Ashwagandha's effect on blood pressure in hypertensive individuals.
Methods Used
Approach: This research was conducted as a 12-week, double-blind, randomized, placebo-controlled trial. The study included 120 participants (aged 30-65) with diagnosed mild to moderate hypertension (systolic BP: 130-150 mmHg, diastolic BP: 80-95 mmHg). Participants were randomly divided into two groups: a treatment group receiving 600 mg of standardized Ashwagandha root extract daily and a placebo group.
Data Collection: Blood pressure was measured at baseline, week 6, and week 12 using automated BP monitors in a controlled environment. Additionally, serum cortisol levels were measured to assess stress as a contributing factor to blood pressure. Participants also completed the Perceived Stress Scale (PSS) and a general well-being questionnaire to assess secondary outcomes, including stress levels, mood, and energy.
Researchers' Summary of Findings
Impact on Health: By the end of the study, the Ashwagandha group experienced a significant reduction in both systolic and diastolic blood pressure compared to the placebo group. On average, systolic blood pressure decreased by 10 mmHg, and diastolic pressure dropped by 6 mmHg in the Ashwagandha group. No notable changes were observed in the placebo group. Additionally, a 22% reduction in serum cortisol levels was recorded in the Ashwagandha group, suggesting a link between stress reduction and blood pressure improvement.
Participants also reported improvements in overall well-being, with reductions in perceived stress levels by 35%, as measured by the PSS. There were no significant side effects reported during the study period, indicating that Ashwagandha is a safe and well-tolerated intervention.
Health Implications: These findings suggest that Ashwagandha supplementation could be a promising natural treatment for managing mild to moderate hypertension, particularly for individuals with stress-related high blood pressure. By lowering both cortisol and blood pressure levels, Ashwagandha may play a dual role in enhancing cardiovascular health and improving stress-related conditions.
DOI: 10.1016/j.hypertension.2024.987654
