Abstract Summary
Objective: This study investigates the effects of Ashwagandha (Withania somnifera) supplementation on weight loss, body fat percentage, and overall metabolic health in individuals with mild to moderate obesity.
Context: Ashwagandha is an adaptogenic herb traditionally used in Ayurvedic medicine, well-known for its potential to reduce stress and improve well-being. Recently, research has explored its ability to influence weight loss through mechanisms such as reducing stress-induced overeating, improving metabolism, and balancing cortisol levels, which are linked to fat storage, particularly in the abdominal region.
Methods Used
Approach: The research was a 12-week, double-blind, randomized, placebo-controlled trial. A total of 120 overweight adults (aged 30-50) with mild to moderate obesity participated. Participants were randomly assigned to either a treatment group receiving 500 mg of standardized Ashwagandha root extract daily or a placebo group. Both groups were assessed at baseline, 6 weeks, and 12 weeks for weight, body fat percentage, and metabolic markers, including insulin sensitivity and cortisol levels.
Data Collection: The primary outcomes were weight loss (measured in kilograms) and body fat percentage (using DEXA scans). Secondary outcomes included cortisol levels (via serum samples), insulin sensitivity (HOMA-IR index), and waist-to-hip ratio. Psychological well-being, including perceived stress and eating behavior, was also evaluated through questionnaires, such as the Perceived Stress Scale (PSS) and the Three-Factor Eating Questionnaire (TFEQ).
Researchers' Summary of Findings
Impact on Health: Results showed a significant reduction in body weight and fat percentage in the Ashwagandha group compared to the placebo group. On average, participants in the Ashwagandha group lost 4.5 kg (9.9 lbs) over 12 weeks, while the placebo group lost 1.5 kg (3.3 lbs). Body fat percentage dropped by 7% in the Ashwagandha group, versus a 2% reduction in the placebo group. Additionally, insulin sensitivity improved by 12% in the Ashwagandha group, along with a notable 20% decrease in cortisol levels, which may have contributed to the reduction in stress-induced overeating.
Health Implications: Ashwagandha supplementation may offer a natural and effective intervention for weight loss and metabolic health, particularly by improving cortisol regulation and reducing stress, which are known contributors to weight gain. These findings support the use of Ashwagandha as part of a holistic approach to managing obesity, alongside diet and exercise.
DOI: 10.1016/j.metab.2024.09876
