Abstract Summary
Objective: This study examines the potential side effects of Ashwagandha (Withania somnifera) on thyroid function in individuals with subclinical hypothyroidism and those with normal thyroid function.
Context: Ashwagandha is commonly used as an adaptogen to promote overall health and well-being. However, there are concerns that the herb may influence thyroid hormone production, particularly in individuals with pre-existing thyroid conditions. This study investigates the potential adverse effects of Ashwagandha on thyroid function by evaluating changes in thyroid-stimulating hormone (TSH), free T3, and free T4 levels.
Methods Used
Approach: A randomized, placebo-controlled, double-blind trial was conducted over a 12-week period. Participants included individuals aged 25-60 years with either subclinical hypothyroidism or normal thyroid function. Participants were divided into two groups, receiving either Ashwagandha root extract (600 mg daily) or a placebo.
Data Collection: Thyroid function was assessed at baseline, week 6, and week 12. Measurements included serum TSH, free T3, and free T4 levels to evaluate thyroid activity. Participants were also monitored for symptoms related to hyperthyroidism and hypothyroidism.
Researchers' Summary of Findings
Impact on Health: The study found that Ashwagandha supplementation significantly increased thyroid hormone levels in individuals with subclinical hypothyroidism, leading to improvements in thyroid function. However, some participants with normal thyroid function experienced mild symptoms of hyperthyroidism, including increased heart rate and anxiety, indicating a potential overstimulation of the thyroid.
Health Implications: Ashwagandha may be beneficial for individuals with underactive thyroid conditions, but caution is advised for individuals with normal thyroid function due to the risk of inducing hyperthyroid symptoms. Healthcare providers should closely monitor thyroid hormone levels in individuals taking Ashwagandha supplements, particularly those with pre-existing thyroid conditions.
DOI: 10.1016/j.thyroidres.2024.015789
