Abstract Summary
Objective: This study investigates the gastrointestinal side effects of Ashwagandha (Withania somnifera) supplementation in healthy adults.
Context: While Ashwagandha is widely recognized for its benefits in stress reduction and immune support, there is growing evidence of potential gastrointestinal disturbances as a side effect of long-term supplementation. This study evaluates the incidence of gastrointestinal symptoms such as nausea, diarrhea, and abdominal pain associated with Ashwagandha use.
Methods Used
Approach: A 10-week observational study was conducted on healthy adults aged 30-55 who were self-administering Ashwagandha root extract (600 mg daily). Participants were monitored for the onset of gastrointestinal symptoms and overall digestive health throughout the study period.
Data Collection: Gastrointestinal symptoms were self-reported by participants through weekly surveys. Specific symptoms measured included nausea, diarrhea, constipation, and abdominal discomfort. Blood tests and stool samples were also collected to assess inflammation markers and gut microbiota changes.
Researchers' Summary of Findings
Impact on Health: The study revealed that 18% of participants reported mild to moderate gastrointestinal discomfort, primarily in the form of nausea and diarrhea. While no severe side effects were reported, participants with pre-existing digestive conditions were more likely to experience symptoms. Stool analysis indicated minor changes in gut microbiota composition but no significant inflammation markers.
Health Implications: Ashwagandha may cause mild gastrointestinal side effects in a subset of individuals, particularly when taken at higher doses. Those with pre-existing digestive issues or sensitive gastrointestinal systems should be cautious when taking Ashwagandha, and it may be beneficial to take the supplement with food to mitigate potential discomfort.
DOI: 10.1016/j.gastrores.2024.011234
