Abstract Summary
Objective: To evaluate the efficacy of curcumin, the active component of turmeric, in reducing pain and improving function in patients with knee osteoarthritis.
Context: Osteoarthritis is a common joint disorder characterized by pain and inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) are often used for treatment but can have adverse effects. Curcumin has been studied as a potential alternative due to its anti-inflammatory properties.
Methods Used
Approach: A randomized, double-blind, placebo-controlled trial was conducted.
Data Collection: Participants with knee osteoarthritis were assigned to receive either 500 mg of curcumin extract twice daily or a placebo for 8 weeks. Outcomes were measured using the Knee Injury and Osteoarthritis Outcome Score (KOOS) and performance-based tests.
Researchers' Summary of Findings
The curcumin group showed significant reductions in knee pain and improvements in physical function compared to the placebo group. Additionally, 37% of participants in the curcumin group reduced their use of pain relief medication, compared to 13% in the placebo group. No significant adverse events were reported, suggesting that curcumin is a safe and effective alternative treatment for knee osteoarthritis.
DOI: 10.3390/nu14010041
