
Modern science has recently become interested in ashwagandha, an herb that is highly valued in Ayurvedic medicine, because of its potential health benefits and anti-inflammatory effects.
As a natural substance that aids in the body's adaptation to stress, ashwagandha root extract, scientifically known as Withania somnifera, is categorized as an adaptogen, reflecting the activity of Withania somnifera.
Used for centuries to enhance mental clarity, physical strength, and overall vitality, it's now being studied for its ability to back those ancient claims with hard science, particularly the effects of ashwagandha root extract.
This article examines the most recent research on ashwagandha, which shows that it can improve sleep and cognitive function in addition to lowering stress and anxiety, highlighting the efficacy and safety of ashwagandha.

How Ashwagandha Affects Stress and Anxiety
Among its most studied benefits is ashwagandha's potential to reduce stress and anxiety, contributing significantly to its overall health benefits, and ashwagandha may also help improve mood.
Several clinical trials suggest it lowers cortisol, the hormone primarily responsible for stress, indicating the impact of ashwagandha on stress levels.
One prominent study found that individuals who took ashwagandha extract had significantly lower cortisol levels than those given a placebo, leading to reduced stress and anxiety symptoms (1).
Another randomized controlled trial revealed that ashwagandha supplementation reduced both anxiety and depressive symptoms in participants.
These results suggest that ashwagandha offers a natural, plant-based alternative to pharmaceutical treatments for managing everyday stress and anxiety and may have a positive effect on overall well-being.
Studies on Ashwagandha for Sleep Improvement
Ashwagandha doesn't just support your mental state during the day—it may also help you get better rest at night, enhancing the positive effects of ashwagandha.
Studies suggest that ashwagandha may improve both sleep duration and quality, particularly in individuals with sleep disorders like insomnia (2).
One study published in the Journal of Dietary Supplements explored the anti-inflammatory effect of ashwagandha.
Cureus published findings that showed that ashwagandha may help improve various health outcomes.
Showed that participants taking ashwagandha fell asleep faster and reported better overall sleep satisfaction.
Scientists believe this is because of its antioxidant properties, which help combat oxidative stress, a major cause of age-related cognitive decline, thereby enhancing the efficacy of ashwagandha.
For those looking for natural sleep solutions without the side effects of sedatives, findings suggest that ashwagandha may be a promising option.
Ashwagandha's Role in Supporting Cognitive Function
Ashwagandha has also shown potential in boosting cognitive performance, especially in older adults and those experiencing mild cognitive impairment, as findings suggest that ashwagandha significantly enhances cognitive function.
A 2017 systematic review and meta-analysis found significant improvements in memory and focus among participants who took ashwagandha extract compared to those who received a placebo, highlighting the effects of Withania somnifera root (3).
Its antioxidant qualities, which aid in preventing oxidative stress, a significant contributor to age-related cognitive decline, are thought to be the effects of Withania somnifera.
Additionally, ashwagandha appears to protect nerve cells, offering possible defense against conditions like Alzheimer's and Parkinson's disease.

Current Research on Ashwagandha and Brain Health
Newer studies are diving deeper into ashwagandha's neuroprotective potential, particularly its role in age-related brain health.
Ashwagandha may slow the progression of Alzheimer's disease by preventing the brain's dangerous amyloid plaques from forming, per a study published in the Journal of Dietary Supplements, showcasing the potential health benefits (4).
Another study showed the herb could improve neural communication, enhance learning capacity, and reduce memory loss over time.
While early results are promising, scientists continue to investigate the long-term effects of ashwagandha on brain health and its potential benefits.
Ashwagandha Studies on Testosterone and Male Health
The impact of ashwagandha on male health is gaining recognition, especially as findings suggest that ashwagandha significantly boosts testosterone and enhances fertility.
In multiple studies, men who took ashwagandha supplements showed significant increases in testosterone levels and improvements in sperm count and motility, highlighting the positive effect of ashwagandha on male reproductive health (5).
Athletes using ashwagandha also demonstrated greater muscle strength and improved endurance compared to those who didn't, as the effects of ashwagandha root extract became evident.
These findings suggest that ashwagandha supports the herb's traditional use as a tonic for male vitality and reproductive performance, and ashwagandha may also positively affect overall health.

Ashwagandha for Women's Health
Although much research has focused on men, ashwagandha offers unique benefits for women, too.
One study found that ashwagandha helped reduce symptoms of menopause, like hot flashes, anxiety, and mood swings.
It may also support thyroid function, a key player in hormonal balance for women.
By promoting healthy thyroid hormone levels, standardized ashwagandha can help alleviate common symptoms of hypothyroidism such as fatigue, low mood, and weight gain.
Side Effects and Safety of Ashwagandha
While generally considered safe, ashwagandha does come with a few considerations regarding the tolerability of ashwagandha root extract.
Common side effects may include sleepiness and gastrointestinal distress, which should be monitored when considering the effects of ashwagandha root extract.
- An upset stomach may occur as a side effect when starting supplementation with ashwagandha.
- Diarrhea can be a side effect to consider when evaluating the tolerability of ashwagandha.
- Nausea can be a common side effect of treatment with ashwagandha.
Potential drug interactions may occur with immunosuppressants and other medications when using a dose of ashwagandha.
- Sedatives may interact with the effects of ashwagandha root extract, so caution is advised regarding the potential health benefits and overall tolerability of ashwagandha.
- Immunosuppressants may interact with the activity of Withania somnifera, so caution is advised when considering ashwagandha.
- Thyroid medications may interact with the activity of ashwagandha, so caution is advised.
Always consult your healthcare provider before beginning ashwagandha, especially if you're pregnant, breastfeeding, or taking other medications, to ensure the safety of ashwagandha per day.
Though not FDA-approved, ashwagandha is widely supported by integrative health professionals for its stress-relieving and wellness-boosting properties.
Final Thoughts
Ashwagandha bridges the gap between ancient wisdom and modern science, particularly in the study of the extract of Withania somnifera.
Its ability to calm the mind, restore hormonal balance, and protect cognitive health makes it a powerful natural ally in today's high-stress world, showcasing the positive effects of ashwagandha.
If you're searching for a way to reclaim your vitality without relying on synthetic solutions, ashwagandha could be the path back to balance.
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FAQs on Benefits of Ashwagandha (Withania Somnifera): What the Science Says
Is ashwagandha scientifically proven to reduce stress?
Yes, several studies show it significantly lowers cortisol levels, the body's primary stress hormone, indicating the positive effect of ashwagandha.
What are the cognitive benefits of ashwagandha?
Ashwagandha may improve memory, enhance focus, and offer protection against age-related neurodegenerative diseases, showcasing its potential health benefits, particularly in the treatment of ashwagandha.
Can ashwagandha improve sleep quality and enhance overall health through its effects?
Research confirms that standardized ashwagandha root extract can improve both sleep onset and quality, especially in those with sleep difficulties, highlighting the potential benefits of ashwagandha root extract.
Is the safety of ashwagandha root extract confirmed for daily use?
Generally, yes, when taken at the recommended mg of ashwagandha doses. Always consult a healthcare provider before use, especially regarding the mg of ashwagandha you should take for optimal efficacy, as ashwagandha may help enhance your wellness journey.
What are the side effects of ashwagandha?
Sleepiness and gastrointestinal distress are examples of mild side effects, which should be monitored when considering the effects of ashwagandha root extract. Serious effects are rare; however, the ashwagandha group reported minimal side effects, indicating a positive effect on tolerance.
Related Studies
1. Title: A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety in adults
Participants taking high-concentration Ashwagandha extract showed significant reductions in cortisol levels and stress compared to placebo over 60 days.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/
2. Title: Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study
This RCT found that Ashwagandha root extract significantly improved sleep quality and reduced anxiety in subjects with insomnia.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096079/
3. Title: A randomized, double-blind, placebo-controlled study of the safety and efficacy of a standardized extract of Withania somnifera (Ashwagandha) in improving memory and cognitive functions in adults
Subjects receiving Ashwagandha for 8 weeks demonstrated significantly better improvements in memory, attention, and information processing speed than those on placebo.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065763/
4. Title: Withania somnifera reverses Alzheimer’s disease pathology by enhancing low-density lipoprotein receptor-related protein in liver
In preclinical models, Ashwagandha extract helped clear amyloid-beta plaques and improved memory through upregulation of LRP in the liver.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655258/
5. Title: Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study
Treatment with Ashwagandha significantly improved sperm count, semen volume, and serum testosterone levels in men diagnosed with oligospermia.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269216/