Abstract Summary
Objective
The objective of this research is to identify the single most validated benefit of ashwagandha, emphasizing consensus from randomized trials, systematic reviews, and pharmacological studies.
Context
Ashwagandha has long been valued in Ayurveda for its adaptogenic effects, and while modern research explores fertility, testosterone, metabolic health, and cognitive outcomes, the evidence for stress and anxiety relief is the most robust and reproducible. Western wellness adoption has further highlighted its use as a natural stress-relief agent for people dealing with chronic anxiety, sleep disturbances, and high cortisol states.
Methods Used
Approach
The approach prioritized placebo-controlled trials with standardized extracts, cross-referenced with meta-analyses for pooled statistical significance. Data were interpreted to highlight consistent clinical outcomes rather than isolated findings, ensuring that the primary benefit identified reflects the strongest scientific consensus.
Data Collection
Data was compiled from PubMed, ScienceDirect, and clinical trial registries. A landmark 2012 randomized trial using 300 mg of KSM-66 twice daily for 60 days showed significant reductions in stress scores and cortisol levels. A 2021 PLOS ONE meta-analysis on sleep also reported improvements in sleep quality among participants taking standardized ashwagandha extracts. The most recent 2025 BJPsych Open meta-analysis provided pooled confirmation that stress and anxiety reduction remain the most consistent benefits observed.
Researchers’ Summary of Findings
Health Implications
Ashwagandha’s strongest application is in reducing stress and anxiety, making it a powerful natural adaptogen for individuals facing chronic stress or poor sleep. This benefit is well documented at moderate daily doses of standardized extracts, with a favorable safety profile for most healthy adults. Although higher doses may be explored for niche conditions, the main health implication remains that ashwagandha is best used as a safe, natural aid for stress regulation and related improvements in sleep and mood.
Sustainability
While the clinical discussion centers on stress relief, growing demand for ashwagandha as a wellness supplement raises sustainability concerns. Ethically sourced, standardized extracts from farms practicing regenerative agriculture help mitigate environmental pressures while meeting global wellness demand.
DOI
10.1192/bjo.2025.10136
