Abstract Summary
Objective: To evaluate the efficacy and safety of ashwagandha root extract in improving thyroid function in patients with subclinical hypothyroidism.
Context: Subclinical hypothyroidism is characterized by elevated thyroid-stimulating hormone (TSH) levels with normal thyroid hormone levels, often leading to nonspecific symptoms. Ashwagandha (Withania somnifera) is an adaptogenic herb traditionally used in Ayurvedic medicine, purported to enhance endocrine function.
Methods Used
Approach: A double-blind, randomized, placebo-controlled trial was conducted over eight weeks. Participants were randomly assigned to receive either 600 mg/day of ashwagandha root extract or a placebo.
Data Collection: Baseline and post-intervention measurements of serum TSH, triiodothyronine (T3), and thyroxine (T4) levels were obtained. Statistical analyses were performed to assess changes in thyroid function markers between the ashwagandha and placebo groups.
Researchers' Summary of Findings
The ashwagandha group exhibited a significant reduction in serum TSH levels and notable increases in T3 and T4 levels compared to the placebo group. These findings suggest that ashwagandha may effectively normalize thyroid indices in subclinical hypothyroid patients.
DOI: 10.1155/2016/6757154
