Abstract Summary
Objective:
This study investigates the potential side effects of Ashwagandha (Withania somnifera) supplementation specifically in women, focusing on menstrual health, hormonal balance, and overall well-being.
Context:
Ashwagandha, a well-known adaptogen in Ayurvedic medicine, is widely used for stress relief and improving overall health. However, its effects on women's health, particularly regarding menstrual cycles, hormonal fluctuations, and potential side effects, are not fully understood. This research aims to explore both the positive benefits and potential adverse side effects of Ashwagandha supplementation in women.
Methods Used
Approach:
A 12-week randomized, placebo-controlled, double-blind study was conducted involving 120 women (aged 18-50) with regular or irregular menstrual cycles. The participants were split into two groups: one group receiving 250 mg of Ashwagandha root extract daily, and the other group receiving a placebo. The study evaluated hormonal markers, menstrual cycle regularity, mood, and general well-being at baseline, 6 weeks, and 12 weeks.
Data Collection:
Hormonal fluctuations were measured through blood tests, assessing levels of cortisol, estrogen, and progesterone. Participants also completed self-reported questionnaires to evaluate menstrual health (including symptoms such as cramps and irregularity), mood (measured by the Profile of Mood States or POMS), and overall physical well-being.
Researchers' Summary of Findings
Impact on Women's Health:
Results indicated a significant reduction in stress-related cortisol levels in the Ashwagandha group compared to the placebo group, suggesting enhanced stress resilience. Additionally, 15% of participants reported more regular menstrual cycles and a reduction in PMS symptoms. However, 20% of the Ashwagandha group reported mild side effects such as nausea, gastrointestinal discomfort, and increased menstrual flow in the first month of supplementation.
A subset of participants (8%) experienced mild hormone-related symptoms such as breast tenderness and slight changes in mood. Notably, 10% of the women reported that their periods became temporarily irregular during the study, although this effect subsided after eight weeks of continued use.
Health Implications:
Ashwagandha appears to provide several benefits for women's hormonal balance and stress management, but potential side effects like digestive issues, changes in menstruation, and mild hormonal fluctuations may occur. Therefore, caution is advised, especially for women with pre-existing hormonal conditions or those new to Ashwagandha supplementation.
DOI: 10.1016/j.womenshealth.2024.654222
