Abstract Summary
Objective: To evaluate the safety profile of KSM-66 Ashwagandha and its potential side effects during regular supplementation.
Context: KSM-66 Ashwagandha is a highly concentrated, standardized extract of the root of the Withania somnifera plant, known for its adaptogenic properties and health benefits such as stress reduction, improved energy levels, and cognitive enhancement. Despite its benefits, there are concerns regarding potential side effects, especially with long-term use.
Methods Used
Approach: A systematic review of clinical trials and observational studies was conducted to assess the incidence of adverse effects related to KSM-66 Ashwagandha supplementation.
Data Collection: Data was sourced from peer-reviewed journals, clinical trials (including randomized controlled trials), and consumer health reports published between 2015 and 2023.
Researchers' Summary of Findings
The majority of clinical studies on KSM-66 Ashwagandha suggest that the supplement is generally safe for most individuals when used according to recommended dosages (250-600 mg/day). Common side effects reported in these studies are mild and include gastrointestinal disturbances such as nausea, diarrhea, or upset stomach. In rare cases, users reported symptoms such as dizziness, fatigue, and drowsiness, which were generally mild and reversible upon discontinuation of the supplement.
However, there are warnings for pregnant and breastfeeding women, as there is insufficient evidence on the safety of Ashwagandha in these populations. Additionally, individuals on certain medications, particularly those for thyroid disorders, diabetes, or immune system-related conditions, should consult a healthcare provider before using KSM-66 Ashwagandha to avoid potential interactions.
DOI: 10.1016/j.jpsychores.2023.110147
