Learn — Deep Dreams

Abstract Summary Objective To evaluate melatonin’s safety and effectiveness as a potential anxiolytic and to define its mechanisms and implications for sustained use. Context Melatonin, a pineal hormone regulating circadian rhythms, is widely used as a sleep aid. Due to the tight interplay between sleep disruption and anxiety, its broader use in anxiety management has become a topic of clinical interest. Methods Use Approach Clinical and preclinical studies were reviewed, emphasizing randomized controlled trials and mechanistic analyses involving melatonin’s role in neural modulation and stress regulation. Data Collection Human trial data included anxiety scores, sleep metrics, cortisol levels, and adverse...

Abstract Summary Objective To determine how the timing of melatonin intake affects sleep quality and duration through analysis of clinical trials and meta-analyses. Context  Melatonin is a hormone that regulates the sleep-wake cycle. Endogenous levels rise one to two hours before bedtime, and taking supplements during this window enhances sleep onset and quality. Dosing too early or too late can reduce benefits or disrupt circadian rhythm. Methods Used Approach A literature review of randomized controlled trials, pharmacokinetic studies, and meta-analyses was conducted to assess the effects of melatonin timing and dosage on sleep outcomes. Data Collection Data were sourced from...