Learn — Ashwagandha Effects

Abstract Summary Objective To determine how you can tell if ashwagandha (Withania somnifera) is working by aligning the outcomes measured in clinical research with observable mental, physical, and physiological changes over time. Context Ashwagandha is an adaptogenic herb traditionally used in Ayurvedic medicine and now widely studied for its effects on stress, anxiety, sleep quality, and stress-related hormonal balance. Most human trials focus on individuals experiencing chronic stress rather than acute illness, making gradual improvement the expected pattern rather than immediate effects. Methods Used Approach This research summary is based on randomized controlled trials and systematic reviews evaluating ashwagandha supplementation...

  Abstract Summary Objective This review evaluates the known side effects and safety concerns associated with ashwagandha (Withania somnifera), with emphasis on gastrointestinal, hepatic, and endocrine effects reported in human studies. Context Ashwagandha is widely used as an adaptogenic herb for stress, sleep, and hormonal support. Still, its increasing use in concentrated supplement form has raised questions about safety, product variability, and suitability for long-term use in diverse populations. Methods Used Approach A focused literature review was conducted using peer-reviewed clinical trials, systematic reviews, case reports, and regulatory assessments to identify and evaluate adverse effects associated with ashwagandha supplementation. Data...

Abstract Summary Objective To assess the physiological effects of ashwagandha (Withania somnifera) on the female body, with specific focus on stress regulation, hormonal balance, reproductive health, and thyroid function. Context Ashwagandha is a well-established adaptogenic herb in Ayurvedic medicine, traditionally used to support stress resilience and endocrine health. Contemporary research has increasingly examined its relevance to women’s health, particularly in relation to chronic stress, menstrual irregularities, hormonal imbalance, and reproductive dysfunction. Its primary mechanism of action appears to involve modulation of the hypothalamic–pituitary–adrenal (HPA) axis. Methods Used Approach A focused review of randomized controlled trials, observational studies, and systematic reviews...

Abstract Summary Objective To evaluate the evidence behind Ashwagandha’s impact on psychological stress, cortisol regulation, cognitive clarity, and sleep quality. Context Ashwagandha (Withania somnifera) is an adaptogenic herb used in traditional Ayurvedic medicine to balance the body’s stress response. Its key compounds, particularly withanolides, modulate the hypothalamic-pituitary-adrenal (HPA) axis, reduce cortisol levels, and promote neurotransmitter balance. This results in calmer mood states, enhanced focus, and improved stress tolerance. Methods Used Approach Systematic review of clinical trials and meta-analyses assessing Ashwagandha’s effects on stress, mood, cognition, and sleep. Data Collection Data included changes in cortisol levels, Perceived Stress Scale (PSS) scores,...