Learn — Ashwaganda

Abstract Summary Objective To evaluate the evidence behind Ashwagandha’s impact on psychological stress, cortisol regulation, cognitive clarity, and sleep quality. Context Ashwagandha (Withania somnifera) is an adaptogenic herb used in traditional Ayurvedic medicine to balance the body’s stress response. Its key compounds, particularly withanolides, modulate the hypothalamic-pituitary-adrenal (HPA) axis, reduce cortisol levels, and promote neurotransmitter balance. This results in calmer mood states, enhanced focus, and improved stress tolerance. Methods Used Approach Systematic review of clinical trials and meta-analyses assessing Ashwagandha’s effects on stress, mood, cognition, and sleep. Data Collection Data included changes in cortisol levels, Perceived Stress Scale (PSS) scores,...

Abstract Summary Objective To evaluate whether ashwagandha (Withania somnifera) should be taken before or after meals by analyzing available clinical, pharmacological, and traditional evidence on absorption, bioavailability, and gastrointestinal tolerance. Context Ashwagandha, a cornerstone of Ayurvedic medicine, is increasingly used in the West for stress reduction, energy balance, and sleep support. Its key active constituents—lipid-soluble withanolides—suggest that timing with food could affect both absorption and tolerability. Ayurveda traditionally recommends taking ashwagandha with milk or ghee to enhance assimilation and reduce potential digestive irritation. Modern consumer guidance often mirrors this, though formal “fed vs. fasted” clinical trials remain scarce. Methods Used...

Abstract Summary Objective To identify the maximum daily dose of ashwagandha (Withania somnifera) supported by clinical research, emphasizing efficacy and safety. Context Ashwagandha, a staple of Ayurvedic medicine, is now widely embraced in Western wellness for stress relief, cognitive enhancement, hormone support, and more. As usage expands, defining a safe upper limit becomes essential, especially for individuals considering higher doses for fertility, sleep, or chronic stress. Methods Used Approach This study involved a structured review of clinical literature and pharmacological trials published between 2000 and 2025. It focused on human studies involving standardized root extracts (e.g., KSM-66, Sensoril) and their...

It's interesting to note that many people have rediscovered ancient herbs in their search for a naturally supportive immune supplement, and ashwagandha is one of the most often mentioned.  Having been utilized for centuries in Ayurvedic medicine, this adaptogenic root has emerged as a significant force in the current supplement market.  But does it really boost the immune system, or is it just another wellness trend cloaked in marketing? What is Ashwagandha? The small shrub known as ashwagandha, or Withania somnifera in scientific parlance, is found in parts of India, the Middle East, and Africa.  The root and berries of...