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Abstract Summary Objective: To evaluate the effects of Ashwagandha (Withania somnifera) supplementation on physical performance, including muscle strength, cardiorespiratory fitness, and fatigue/recovery, in healthy individuals. Context: Ashwagandha is traditionally recognized for its adaptogenic properties, potentially enhancing physical performance and vitality. This study systematically reviews and analyzes clinical trials to assess its efficacy in improving physical performance metrics. Methods Used Approach: A systematic review and Bayesian meta-analysis were conducted, adhering to PRISMA guidelines, to evaluate the impact of Ashwagandha supplementation on physical performance. Data Collection: Databases including PubMed, ScienceDirect, and Google Scholar were searched for clinical trials up to 2020. Thirteen...

Abstract Summary Objective: To evaluate the impact of ashwagandha (Withania somnifera) supplementation on cortisol levels in individuals experiencing stress. Context: Ashwagandha, a traditional adaptogenic herb, is reputed for its stress-reducing properties. This study investigates its efficacy in modulating cortisol, a primary stress hormone. Methods Used Approach: A systematic review and meta-analysis of randomized controlled trials (RCTs) assessing the effects of ashwagandha on cortisol levels. Data Collection: Comprehensive searches were conducted across databases including PubMed, EMBASE, and Scopus up to December 2023. Inclusion criteria encompassed RCTs involving ashwagandha supplementation with reported cortisol measurements. Researchers' Summary of Findings The analysis incorporated nine...

Abstract Summary Objective: To evaluate the efficacy and safety of ashwagandha root extract in improving thyroid function in patients with subclinical hypothyroidism. Context: Subclinical hypothyroidism is characterized by elevated thyroid-stimulating hormone (TSH) levels with normal thyroid hormone levels, often leading to nonspecific symptoms. Ashwagandha (Withania somnifera) is an adaptogenic herb traditionally used in Ayurvedic medicine, purported to enhance endocrine function. Methods Used Approach: A double-blind, randomized, placebo-controlled trial was conducted over eight weeks. Participants were randomly assigned to receive either 600 mg/day of ashwagandha root extract or a placebo. Data Collection: Baseline and post-intervention measurements of serum TSH, triiodothyronine (T3),...

Abstract Summary Objective: To evaluate the efficacy and safety of topical Ashwagandha (Withania somnifera) lotion on photoaged facial skin in healthy adults. Context: Photoaging, resulting from prolonged sun exposure, leads to skin damage characterized by wrinkles, pigmentation, and loss of elasticity. Ashwagandha, known for its adaptogenic properties, has been traditionally used in Ayurvedic medicine for rejuvenation. This study investigates its potential benefits when applied topically to photoaged skin. Methods Used Approach: A randomized, double-blind, placebo-controlled clinical trial. Data Collection: Fifty-six healthy men and women aged 18 to 60 with Fitzpatrick skin types III-VI were enrolled. Participants were randomly assigned to...