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Abstract Summary Objective: To evaluate the efficacy of curcumin and nano-curcumin in alleviating chronic pain in both clinical and preclinical settings. Context: Chronic pain presents significant treatment challenges. Curcumin, a natural compound in the Curcuma genus, is known for its anti-inflammatory, antioxidant, and neuroprotective properties. Methods Used Approach: A systematic review and meta-analysis were conducted to assess the analgesic effects of curcumin and nano-curcumin. Data Collection: Comprehensive searches were performed across PubMed, SCOPUS, Web of Science Core Collection, Cochrane, and Google Scholar up to April 1, 2023. Studies meeting the inclusion criteria were analyzed using mean difference (MD) or standardized...

Abstract Summary Objective: To evaluate the efficacy of curcumin, the active component of turmeric, in reducing pain and improving function in patients with knee osteoarthritis. Context: Osteoarthritis is a common joint disorder characterized by pain and inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) are often used for treatment but can have adverse effects. Curcumin has been studied as a potential alternative due to its anti-inflammatory properties. Methods Used Approach: A randomized, double-blind, placebo-controlled trial was conducted. Data Collection: Participants with knee osteoarthritis were assigned to receive either 500 mg of curcumin extract twice daily or a placebo for 8 weeks. Outcomes were measured...

Abstract Summary Objective: To evaluate the safety and efficacy of ashwagandha root extract in improving sexual health in healthy women. Context: Ashwagandha (Withania somnifera) is widely used for its adaptogenic and aphrodisiac properties. Despite its traditional use in enhancing sexual health, scientific evidence supporting its safety and effectiveness in women is limited. Methods Used Approach: The study used a randomized, double-blind, placebo-controlled methodology to ensure unbiased results. Data Collection: Healthy female participants were divided into two groups: one receiving ashwagandha root extract and the other receiving a placebo for eight weeks. Researchers collected data on sexual health outcomes through validated...

Abstract Summary Objective: To evaluate the efficacy and safety of an eight-week therapy with Ashwagandha Root Extract (ARE) in improving sexual health in healthy adult men. Context: Ashwagandha, a traditional Indian Ayurvedic remedy, is known for its adaptogenic properties and potential benefits in enhancing sexual function in both men and women. Methods Used Approach: A prospective, randomized, double-blind, placebo-controlled study was conducted over eight weeks. Participants were randomly assigned to receive either 300 mg of ARE twice daily or a placebo. Data Collection: The study assessed outcomes using the Satisfying Sexual Events (SSEs) metric, the Sexual Desire Inventory (SDI-2), the...