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Abstract Summary Objective To assess what ashwagandha (Withania somnifera) is scientifically supported to be good for, with a focus on stress reduction, cortisol regulation, sleep quality, and overall well-being. Context Ashwagandha is an adaptogenic herb used in Ayurvedic medicine to support the body’s stress response. Its primary bioactive compounds, withanolides, influence the hypothalamic-pituitary-adrenal (HPA) axis and cortisol regulation. Through these mechanisms, ashwagandha may promote calmer mood states, improved sleep, and greater stress resilience. Methods Used Approach This review draws from systematic reviews, meta-analyses, and randomized controlled trials evaluating ashwagandha supplementation in humans, with emphasis on stress, anxiety, cortisol, and sleep-related...

People without the need for a prescription look to daily use of vitamins and supplements all the time, but especially when taking them as a long-term habit, many pause. 　　 Is it safe to take ashwagandha daily? : A question worth asking. Since herbal supplements are not pharmaceuticals, their adverse effects are contingent upon their quality, dosage, and personal health conditions. Ashwagandha has been used traditionally for a long time, but there isn't enough research to reassure modern users that using it on a daily basis won't harm them. Understanding the safety of Ashwagandha In traditional medicine, ashwagandha has been...

Abstract Summary Objective To identify populations who should not take ashwagandha (Withania somnifera) by evaluating clinical safety data, regulatory guidance, and documented adverse effects, with emphasis on contraindications, high-risk health conditions, and drug interactions. Context Ashwagandha is widely promoted for stress reduction, sleep support, and hormonal balance. As its use has expanded globally, safety concerns have emerged regarding its suitability for certain individuals. Regulatory agencies and clinical researchers have highlighted specific groups for whom ashwagandha may pose health risks, particularly related to pregnancy, liver health, autoimmune activity, and medication interactions. Methods Used Approach A narrative review of safety-focused literature was...

Abstract Summary Objective To assess whether ashwagandha (Withania somnifera) is effective in reducing anxiety symptoms, particularly those related to chronic stress, and to review its safety profile. Context Ashwagandha is an adaptogenic herb used in Ayurvedic medicine to support stress resilience and emotional balance. Contemporary research primarily examines its effects in adults with high stress or mild-to-moderate anxiety symptoms, rather than severe anxiety disorders, positioning it as a supportive—not replacement—intervention. Methods Used Approach A concise review of randomized controlled trials and recent systematic reviews was conducted, focusing on human studies that evaluated anxiety outcomes using validated psychological scales and standardized...